Gradient moduli lens models: how material properties and application of forces can affect deformation and distributions of stress

The human lens provides one-third of the ocular focussing power and is responsible for altering focus over a range of distances. This ability, termed accommodation, defines the process by which the lens alters shape to increase or decrease ocular refractive power; this is mediated by the ciliary muscle through the zonule. This ability decreases with age such that around the sixth decade of life it is lost rendering the eye unable to focus on near objects. There are two opponent theories that provide an explanation for the mechanism of accommodation; definitive support for either of these requires investigation. This work aims to elucidate how material properties can affect accommodation using Finite Element models based on interferometric measurements of refractive index. Gradients of moduli are created in three models from representative lenses, aged 16, 35 and 48 years. Different forms of zonular attachments are studied to determine which may most closely mimic the physiological form by comparing stress and displacement fields with simulated shape changes to accommodation in living lenses. The results indicate that for models to mimic accommodation in living eyes, the anterior and posterior parts of the zonule need independent force directions. Choice of material properties affects which theory of accommodation is supported

Managing Technology Transfer Challenges in the Renewable Energy Sector within the European Union

The use of fossil fuels to generate energy is often associated with serious negative effects on the environment. The greenhouse gas emissions resulting from burning these fuels destroy the ozone layer and lead to global warming. As a strategic approach to the solution of this problem, calls for research and development, as well as the implementation of technologies associated with renewable energy sources within the European Union (EU), have intensified in recent years. One of the keys to a successful outcome from this intensified effort is to identify the challenges associated with the transfer of both intellectual property and technology rights in the renewable energy sector within the EU. The present paper contributes towards this direction. Firstly, data from the literature were used to identify contemporary trends within the European Union with regards to technology transfer and intellectual property within the sector of renewable energy. Then, a statistical analysis utilising an ordinary least squares (OLS) model was conducted to establish a correlation between renewable energy innovations (research and development) and the level of investment associated with renewable energy technologies. Finally, this correlation, along with the associated challenges, was then critically explored for four of the most popular renewable energy sources (namely solar energy, biomass, wind energy, and marine renewable energy), and conclusions are reporte

The role of morphology of the thumb in anthropomorphic grasping : a review

The unique musculoskeletal structure of the human hand brings in wider dexterous capabilities to grasp and manipulate a repertoire of objects than the non-human primates. It has been widely accepted that the orientation and the position of the thumb plays an important role in this characteristic behavior. There have been numerous attempts to develop anthropomorphic robotic hands with varying levels of success. Nevertheless, manipulation ability in those hands is to be ameliorated even though they can grasp objects successfully. An appropriate model of the thumb is important to manipulate the objects against the fingers and to maintain the stability. Modeling these complex interactions about the mechanical axes of the joints and how to incorporate these joints in robotic thumbs is a challenging task. This article presents a review of the biomechanics of the human thumb and the robotic thumb designs to identify opportunities for future anthropomorphic robotic hands

A modelling approach for investigating opto-mechanical relationships in the human eye lens

Objective: The human visual system alters its focus by a shape change of the eye lens. The extent to which the lens can adjust ocular refractive power is dependent to a significant extent on its material properties. Yet, this fundamental link between the optics and mechanics of the lens has been relatively under investigated. This study aims to investigate this opto-mechanical link within the eye lens to gain insight into the processes of shape alteration and their respective decline with age. Methods: Finite Element models based on biological lenses were developed for five ages: 16, 35, 40, 57 and 62 years by correlating in vivo measurements of the longitudinal modulus using Brillouin scattering with in vitro X-ray interferometric measurements of refractive index and taking into account various directions of zonular force. Results: A model with radial cortical Young’s moduli provides the same amount of refractive power with less change in thickness than a model with uniform cortical Young’s modulus with a uniform stress distribution and no discontinuities along the cortico-nuclear boundary. The direction of zonular angles can significantly influence curvature change regardless of the modulus distribution. Conclusions: The present paper proposes a modelling approach for the human lens, coupling optical and mechanical properties, which shows the effect of parameter choice on model response. Significance: This advanced modelling approach, considering the important interplay between optical and mechanical properties, has potential for use in design of accommodating implant lenses and for investigating non-biological causes of pathological processes in the lens (e.g. cataract)

Combined use of parallel-plate compression and finite element modeling to analyze the mechanical properties of intact porcine lens

The objective of this study is to explore the feasibility of a compression test for measuring mechanical properties of intact eye lenses using novel parallel plate compression equipment to compare the accuracy of implementing a classical Hertzian model and a newly proposed adjusted Hertzian model to calculate Young’s modulus from compression test results using finite element (FE) analysis. Parallel-plate compression tests were performed on porcine lenses. An axisymmetric FE model was developed to simulate the experimental process to evaluate the accuracy of using the classical Hertzian theory of contact mechanics as well as a newly proposed adjusted Hertzian theory model for calculating the equivalent Young’s modulus. By fitting the force-displacement relation obtained from FE simulations to both the classical and adjusted Hertzian theory model and comparing the calculated modulus to the input modulus of the FE model, the results demonstrated that the classical Hertzian theory model overestimated the Young’s modulus with a proportional error of over 10%. The adjusted Hertzian theory model produced results that are closer to original input values with error ratios all lower than 1.29%. Measurements of three porcine lenses from the parallel plate compression experiments were analyzed with resulting values of Young’s modulus of between 3.2kPa and 4.3kPa calculated. This study demonstrates that the adjusted Hertzian theory of contact mechanics can be applied in conjunction with the parallel-plate compression system to investigate the overall mechanical behavior of intact lenses

Enumeration search method for optimisation of stacking sequence of laminated composite plates subjected to buckling

Enumeration search method (ESM) checks all possible combinations of design variables in a bottom-up approach until it finds the global optimum solution for the design conditions. In this paper an optimum design of a multilayered laminated plate made of unidirectional fibre reinforced polymer (FRP) composite subject to uniaxial compression is sought.ESMtogether with classical laminated plate theory (CLPT) has been used to find the lightest laminate for maximizing the buckling load capable of providing structural stability for a set target uniaxial compression load. The choice of the design variables is limited to 4 possible fibres orientation angles (0,90,-45,+45) and the sequence of the laminate, making the problem an integer programming. Experimental and finite element analyses were used to verify the optimum solution. It has been shown that the exhaustive enumeration search method is a powerful tool for finding the global optimum design